Linear Immunoglobulin A Bullous Dermatosis

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Sulfasalazine-induced linear immunoglobulin A bullous dermatosis with DRESS.

Linear immunoglobulin (Ig) A dermatosis is an immune-mediated bullous disease characterized by linear deposits of IgA along the basal membrane. While usually idiopathic, it can occasionally be induced by drug exposure. We report the case of a 60-year-old woman with rheumatoid arthritis being treated with sulfasalazine who developed linear IgA dermatosis and drug rash with eosinophilia and syste...

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Linear IgA Bullous Dermatosis

Figure 1. Clinical photograph of linear IgA bullous dermatosis showing tense bullae and erosions involving the lower abdomen, inner thighs, and extremities.

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Interstitial pneumonia associated with linear immunoglobulin A/immunoglobulin G bullous dermatosis.

A 76-year-old man with interstitial lung disease was admitted to our institution after developing persistent dyspnea upon effort. He also had a relapse of bullous eruptions on the skin of the trunk and extremities, previously diagnosed as vesicular pemphigoid. Direct immunofluorescence of a skin biopsy specimen using fluorescence microscopy showed the linear deposition of immunglobulin A (IgA),...

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A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis

Linear IgA bullous dermatosis (LABD) is an autoimmune vesiculobullous disease, which is typically idiopathic but can also rarely be caused by medications or infections. Vancomycin is the most common drug associated with LABD. Lesions typically appear 24 hours to 15 days after the first dose of vancomycin. It is best characterized pathologically by subepidermal bulla (blister) formation with lin...

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Linear IgA and IgG bullous dermatosis*

Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be...

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ژورنال

عنوان ژورنال: The Journal of Pediatrics

سال: 2016

ISSN: 0022-3476

DOI: 10.1016/j.jpeds.2015.11.078